Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1

Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 ex...

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Autores principales: Yin, Chunsheng, Chen, Weiye, Hu, Qianqian, Wen, Zhiyuan, Wang, Xijun, Ge, Jinying, Yin, Qianqian, Zhi, Haibing, Xia, Chun, Bu, Zhigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059095/
https://www.ncbi.nlm.nih.gov/pubmed/24898430
http://dx.doi.org/10.1186/1297-9716-45-62
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author Yin, Chunsheng
Chen, Weiye
Hu, Qianqian
Wen, Zhiyuan
Wang, Xijun
Ge, Jinying
Yin, Qianqian
Zhi, Haibing
Xia, Chun
Bu, Zhigao
author_facet Yin, Chunsheng
Chen, Weiye
Hu, Qianqian
Wen, Zhiyuan
Wang, Xijun
Ge, Jinying
Yin, Qianqian
Zhi, Haibing
Xia, Chun
Bu, Zhigao
author_sort Yin, Chunsheng
collection PubMed
description Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant virus in vitro and immunogenicity in inducing neutralizing antibody against PPR in goats. Vaccination with one dose of rPPRV/VP1 induced FMDV neutralizing antibody in goats and protected them from challenge with virulent FMDV. Our results suggest that the recombinant PPRV expressing the FMDV VP1 protein is a potential dual live vectored vaccine against PPRV and FMDV.
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spelling pubmed-40590952014-06-17 Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1 Yin, Chunsheng Chen, Weiye Hu, Qianqian Wen, Zhiyuan Wang, Xijun Ge, Jinying Yin, Qianqian Zhi, Haibing Xia, Chun Bu, Zhigao Vet Res Research Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant virus in vitro and immunogenicity in inducing neutralizing antibody against PPR in goats. Vaccination with one dose of rPPRV/VP1 induced FMDV neutralizing antibody in goats and protected them from challenge with virulent FMDV. Our results suggest that the recombinant PPRV expressing the FMDV VP1 protein is a potential dual live vectored vaccine against PPRV and FMDV. BioMed Central 2014 2014-06-04 /pmc/articles/PMC4059095/ /pubmed/24898430 http://dx.doi.org/10.1186/1297-9716-45-62 Text en Copyright © 2014 Yin et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Yin, Chunsheng
Chen, Weiye
Hu, Qianqian
Wen, Zhiyuan
Wang, Xijun
Ge, Jinying
Yin, Qianqian
Zhi, Haibing
Xia, Chun
Bu, Zhigao
Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1
title Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1
title_full Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1
title_fullStr Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1
title_full_unstemmed Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1
title_short Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1
title_sort induction of protective immune response against both pprv and fmdv by a novel recombinant pprv expressing fmdv vp1
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059095/
https://www.ncbi.nlm.nih.gov/pubmed/24898430
http://dx.doi.org/10.1186/1297-9716-45-62
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