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Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions

BACKGROUND: Suppression of body weight and symptom of anorexia are major symptoms of depression. Recently, we reported that chronic social defeat stress (CSDS) induced suppression of body weight gain and anorexic feeding behavior in rats. These abnormalities were the result of disrupted malonyl-coen...

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Autores principales: Iio, Wataru, Takagi, Haruyoshi, Ogawa, Yasuki, Tsukahara, Takamitsu, Chohnan, Shigeru, Toyoda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059170/
https://www.ncbi.nlm.nih.gov/pubmed/24906408
http://dx.doi.org/10.1186/1471-2202-15-72
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author Iio, Wataru
Takagi, Haruyoshi
Ogawa, Yasuki
Tsukahara, Takamitsu
Chohnan, Shigeru
Toyoda, Atsushi
author_facet Iio, Wataru
Takagi, Haruyoshi
Ogawa, Yasuki
Tsukahara, Takamitsu
Chohnan, Shigeru
Toyoda, Atsushi
author_sort Iio, Wataru
collection PubMed
description BACKGROUND: Suppression of body weight and symptom of anorexia are major symptoms of depression. Recently, we reported that chronic social defeat stress (CSDS) induced suppression of body weight gain and anorexic feeding behavior in rats. These abnormalities were the result of disrupted malonyl-coenzyme A (CoA) signaling pathway in the hypothalamus. However, the condition of peripheral leptin and its hypothalamic downstream signal molecules which regulate hypothalamic malonyl-CoA level in the CSDS-exposed rats (CSDS rats) is still unknown. RESULTS: CSDS rats showed suppressed body weight gain and food intake. The weight of the CSDS rats’ epididymal white adipose tissues was decreased when compared to the control rats. The plasma cholesterol concentration was decreased significantly in the CSDS rats compared to the control rats (P < 0.05). The plasma glucose concentration was slightly decreased in the CSDS rats compared to the control rats (P < 0.1). The expression of leptin mRNA in epididymal white adipose tissues and the plasma leptin concentration were decreased in CSDS rats. Furthermore, the phosphorylation of the hypothalamic downstream signals of leptin, including extracellular signal-regulated kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3), was decreased in CSDS rats. CONCLUSIONS: Our results indicated that decreased peripheral leptin expression in CSDS rats could down-regulate the hypothalamic downstream signaling pathways of leptin while suppressed food intake. These data indicate that CSDS induces the down-regulation of hypothalamic AMPK following the elevation of hypothalamic malonyl-CoA levels and is independent of peripheral leptin and glucose.
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spelling pubmed-40591702014-06-17 Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions Iio, Wataru Takagi, Haruyoshi Ogawa, Yasuki Tsukahara, Takamitsu Chohnan, Shigeru Toyoda, Atsushi BMC Neurosci Research Article BACKGROUND: Suppression of body weight and symptom of anorexia are major symptoms of depression. Recently, we reported that chronic social defeat stress (CSDS) induced suppression of body weight gain and anorexic feeding behavior in rats. These abnormalities were the result of disrupted malonyl-coenzyme A (CoA) signaling pathway in the hypothalamus. However, the condition of peripheral leptin and its hypothalamic downstream signal molecules which regulate hypothalamic malonyl-CoA level in the CSDS-exposed rats (CSDS rats) is still unknown. RESULTS: CSDS rats showed suppressed body weight gain and food intake. The weight of the CSDS rats’ epididymal white adipose tissues was decreased when compared to the control rats. The plasma cholesterol concentration was decreased significantly in the CSDS rats compared to the control rats (P < 0.05). The plasma glucose concentration was slightly decreased in the CSDS rats compared to the control rats (P < 0.1). The expression of leptin mRNA in epididymal white adipose tissues and the plasma leptin concentration were decreased in CSDS rats. Furthermore, the phosphorylation of the hypothalamic downstream signals of leptin, including extracellular signal-regulated kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3), was decreased in CSDS rats. CONCLUSIONS: Our results indicated that decreased peripheral leptin expression in CSDS rats could down-regulate the hypothalamic downstream signaling pathways of leptin while suppressed food intake. These data indicate that CSDS induces the down-regulation of hypothalamic AMPK following the elevation of hypothalamic malonyl-CoA levels and is independent of peripheral leptin and glucose. BioMed Central 2014-06-06 /pmc/articles/PMC4059170/ /pubmed/24906408 http://dx.doi.org/10.1186/1471-2202-15-72 Text en Copyright © 2014 Iio et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Iio, Wataru
Takagi, Haruyoshi
Ogawa, Yasuki
Tsukahara, Takamitsu
Chohnan, Shigeru
Toyoda, Atsushi
Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
title Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
title_full Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
title_fullStr Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
title_full_unstemmed Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
title_short Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
title_sort effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059170/
https://www.ncbi.nlm.nih.gov/pubmed/24906408
http://dx.doi.org/10.1186/1471-2202-15-72
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