Cargando…
Total Synthesis of the Antitumor Natural Product Polycarcin V and Evaluation of Its DNA Binding Profile
[Image: see text] The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the sequence features a stereos...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059221/ https://www.ncbi.nlm.nih.gov/pubmed/24824354 http://dx.doi.org/10.1021/ol501095w |