Synthesis of Enantiopure 10-Nornaltrexones in the Search for Toll-like Receptor 4 Antagonists and Opioid Ligands

[Image: see text] 10-Nornaltrexones (3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-benzofuro[3,2-e]isoquinolin-7(7aH)-one, 1) have been underexploited in the search for better opioid ligands, and their enantiomers have been unexplored. The synthesis of trans-isoquinolinone 2 (4-aH,...

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Detalles Bibliográficos
Autores principales: Selfridge, Brandon R., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059225/
https://www.ncbi.nlm.nih.gov/pubmed/24773391
http://dx.doi.org/10.1021/jo500568s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059225/
https://www.ncbi.nlm.nih.gov/pubmed/24773391
http://dx.doi.org/10.1021/jo500568s

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