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Design, Synthesis, and Structure–Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors

[Image: see text] RNA polymerase I (Pol I) is a dedicated polymerase that transcribes the 45S ribosomal (r) RNA precursor. The 45S rRNA precursor is subsequently processed into the mature 5.8S, 18S, and 28S rRNAs and assembled into ribosomes in the nucleolus. Pol I activity is commonly deregulated i...

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Detalles Bibliográficos
Autores principales:	Colis, Laureen, Ernst, Glen, Sanders, Sara, Liu, Hester, Sirajuddin, Paul, Peltonen, Karita, DePasquale, Michael, Barrow, James C., Laiho, Marikki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059246/ https://www.ncbi.nlm.nih.gov/pubmed/24847734 http://dx.doi.org/10.1021/jm5004842

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