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Efficient Access to 2,3-Diarylimidazo[1,2-a]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction under Microwave Irradiation

[Image: see text] An expeditious one-pot, ligand-free, Pd(OAc)(2)-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversi...

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Detalles Bibliográficos
Autores principales: Wang, Yuanxiang, Frett, Brendan, Li, Hong-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059256/
https://www.ncbi.nlm.nih.gov/pubmed/24854606
http://dx.doi.org/10.1021/ol501136e
Descripción
Sumario:[Image: see text] An expeditious one-pot, ligand-free, Pd(OAc)(2)-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines analogues.