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Influence of the Length and Positioning of the Antiestrogenic Side Chain of Endoxifen and 4-Hydroxytamoxifen on Gene Activation and Growth of Estrogen Receptor Positive Cancer Cells

[Image: see text] Tamoxifen has biologically active metabolites: 4-hydroxytamoxifen (4OHT) and endoxifen. The E-isomers are not stable in solution as Z-isomerization occurs. We have synthesized fixed ring (FR) analogues of 4OHT and endoxifen as well as FR E and Z isomers with methoxy and ethoxy side...

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Detalles Bibliográficos
Autores principales:	Maximov, Philipp Y., Fernandes, Daphne J., McDaniel, Russell E., Myers, Cynthia B., Curpan, Ramona F., Jordan, V. Craig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059272/ https://www.ncbi.nlm.nih.gov/pubmed/24805199 http://dx.doi.org/10.1021/jm500569h

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