Regulation of HIV-Gag Expression and Targeting to the Endolysosomal/Secretory Pathway by the Luminal Domain of Lysosomal-Associated Membrane Protein (LAMP-1) Enhance Gag-Specific Immune Response

We have previously demonstrated that a DNA vaccine encoding HIV-p55gag in association with the lysosomal associated membrane protein-1 (LAMP-1) elicited a greater Gag-specific immune response, in comparison to a DNA encoding the native gag. In vitro studies have also demonstrated that LAMP/Gag was h...

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Detalles Bibliográficos
Autores principales: Godinho, Rodrigo Maciel da Costa, Matassoli, Flavio Lemos, Lucas, Carolina Gonçalves de Oliveira, Rigato, Paula Ordonhez, Gonçalves, Jorge Luiz Santos, Sato, Maria Notomi, Maciel, Milton, Peçanha, Ligia Maria Torres, August, J. Thomas, de Azevedo Marques, Ernesto Torres, de Arruda, Luciana Barros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059647/
https://www.ncbi.nlm.nih.gov/pubmed/24932692
http://dx.doi.org/10.1371/journal.pone.0099887

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