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Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock
OBJECTIVE: Anaphylaxis is the most severe form of radiocontrast media (RCM) induced hypersensitivity and can be life-threatening if profound hypotension is combined. With increased use of iodine based RCM, related hypersensitivity is rapidly growing. However, the clinical characteristics and risk fa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059752/ https://www.ncbi.nlm.nih.gov/pubmed/24932635 http://dx.doi.org/10.1371/journal.pone.0100154 |
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author | Kim, Min-Hye Lee, Suh-Young Lee, Seung-Eun Yang, Min-Suk Jung, Jae-Woo Park, Chang Min Lee, Whal Cho, Sang-Heon Kang, Hye-Ryun |
author_facet | Kim, Min-Hye Lee, Suh-Young Lee, Seung-Eun Yang, Min-Suk Jung, Jae-Woo Park, Chang Min Lee, Whal Cho, Sang-Heon Kang, Hye-Ryun |
author_sort | Kim, Min-Hye |
collection | PubMed |
description | OBJECTIVE: Anaphylaxis is the most severe form of radiocontrast media (RCM) induced hypersensitivity and can be life-threatening if profound hypotension is combined. With increased use of iodine based RCM, related hypersensitivity is rapidly growing. However, the clinical characteristics and risk factors of RCM induced anaphylaxis accompanied by hypotension (anaphylactic shock) are not clearly defined. This study was performed to investigate the risk factors of RCM induced anaphylactic shock and the clinical value of RCM skin testing to identify causative agents in affected patients. METHODS: We analyzed the data of RCM induced anaphylaxis monitored by an inhospital pharmacovigilance center at a tertiary teaching hospital from January 2005 to December 2012 and compared the clinical features and skin test results according to the accompanying hypotension. RESULTS: Among total of 104 cases of RCM induced anaphylaxis, 34.6% of patients, developed anaphylaxis on their first exposure to RCM. Anaphylactic patients presenting with shock were older (57.4 vs. 50.1 years, p = 0.026) and had a history of more frequently exposure to RCM (5.1±7.8 vs. 1.9±3.3, p = 0.004) compared to those without hypotension. Among RCMs, hypotension was more frequent in anaphylaxis related to iopromide compared to other agents (85.0% vs. 61.4%, p = 0.011). Skin tests were performed in 51 patients after development of RCM induced anaphylaxis. Overall skin test positivity to RCM was 64.7% and 81.8% in patients with anaphylactic shock. CONCLUSION: RCM induced anaphylactic shock is related to multiple exposures to RCM and most patients showed skin test positivity to RCM. |
format | Online Article Text |
id | pubmed-4059752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40597522014-06-19 Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock Kim, Min-Hye Lee, Suh-Young Lee, Seung-Eun Yang, Min-Suk Jung, Jae-Woo Park, Chang Min Lee, Whal Cho, Sang-Heon Kang, Hye-Ryun PLoS One Research Article OBJECTIVE: Anaphylaxis is the most severe form of radiocontrast media (RCM) induced hypersensitivity and can be life-threatening if profound hypotension is combined. With increased use of iodine based RCM, related hypersensitivity is rapidly growing. However, the clinical characteristics and risk factors of RCM induced anaphylaxis accompanied by hypotension (anaphylactic shock) are not clearly defined. This study was performed to investigate the risk factors of RCM induced anaphylactic shock and the clinical value of RCM skin testing to identify causative agents in affected patients. METHODS: We analyzed the data of RCM induced anaphylaxis monitored by an inhospital pharmacovigilance center at a tertiary teaching hospital from January 2005 to December 2012 and compared the clinical features and skin test results according to the accompanying hypotension. RESULTS: Among total of 104 cases of RCM induced anaphylaxis, 34.6% of patients, developed anaphylaxis on their first exposure to RCM. Anaphylactic patients presenting with shock were older (57.4 vs. 50.1 years, p = 0.026) and had a history of more frequently exposure to RCM (5.1±7.8 vs. 1.9±3.3, p = 0.004) compared to those without hypotension. Among RCMs, hypotension was more frequent in anaphylaxis related to iopromide compared to other agents (85.0% vs. 61.4%, p = 0.011). Skin tests were performed in 51 patients after development of RCM induced anaphylaxis. Overall skin test positivity to RCM was 64.7% and 81.8% in patients with anaphylactic shock. CONCLUSION: RCM induced anaphylactic shock is related to multiple exposures to RCM and most patients showed skin test positivity to RCM. Public Library of Science 2014-06-16 /pmc/articles/PMC4059752/ /pubmed/24932635 http://dx.doi.org/10.1371/journal.pone.0100154 Text en © 2014 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Min-Hye Lee, Suh-Young Lee, Seung-Eun Yang, Min-Suk Jung, Jae-Woo Park, Chang Min Lee, Whal Cho, Sang-Heon Kang, Hye-Ryun Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock |
title | Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock |
title_full | Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock |
title_fullStr | Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock |
title_full_unstemmed | Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock |
title_short | Anaphylaxis to Iodinated Contrast Media: Clinical Characteristics Related with Development of Anaphylactic Shock |
title_sort | anaphylaxis to iodinated contrast media: clinical characteristics related with development of anaphylactic shock |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059752/ https://www.ncbi.nlm.nih.gov/pubmed/24932635 http://dx.doi.org/10.1371/journal.pone.0100154 |
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