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Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes and are versatile experimental tools to explore the contribution of individual genetic alter...

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Detalles Bibliográficos
Autores principales:	Charles, Joël P., Fuchs, Jeannette, Hefter, Mirjam, Vischedyk, Jonas B., Kleint, Maximilian, Vogiatzi, Fotini, Schäfer, Jonas A., Nist, Andrea, Timofeev, Oleg, Wanzel, Michael, Stiewe, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059931/ https://www.ncbi.nlm.nih.gov/pubmed/24889111 http://dx.doi.org/10.1038/ncomms4981

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