Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing

The G2 checkpoint monitors DNA damage, preventing mitotic entry until the damage can be resolved. The mechanisms controlling checkpoint recovery are unclear. Here, we identify non-genetic heterogeneity in the fidelity and timing of damage-induced G2 checkpoint enforcement in individual cells from th...

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Detalles Bibliográficos
Autores principales: Liang, Hongqing, Esposito, Alessandro, De, Siddharth, Ber, Suzan, Collin, Philippe, Surana, Uttam, Venkitaraman, Ashok R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059941/
https://www.ncbi.nlm.nih.gov/pubmed/24893992
http://dx.doi.org/10.1038/ncomms5048

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