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Pathogenesis and Causes of Premature Ovarian Failure: An Update
Genetic disorders, which could involve the X chromosome or autosomes. However, the growing body of literature demonstrates a list of newly discovered mutations that may be responsible for causing POF. Most of these mutations are extremely rare, and most cases of POF are still considered to be idiopa...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059950/ https://www.ncbi.nlm.nih.gov/pubmed/24963360 |
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author | Ebrahimi, Mahbod Akbari Asbagh, Firoozeh |
author_facet | Ebrahimi, Mahbod Akbari Asbagh, Firoozeh |
author_sort | Ebrahimi, Mahbod |
collection | PubMed |
description | Genetic disorders, which could involve the X chromosome or autosomes. However, the growing body of literature demonstrates a list of newly discovered mutations that may be responsible for causing POF. Most of these mutations are extremely rare, and most cases of POF are still considered to be idiopathic. Autoimmune causes; there is some evidence of an association of POF with lymphocytic oophoritis and other autoimmune disorders. Antiovarian antibodies are reported in POF, but their specificity and pathogenic role are obscure. Iatrogenic causes; chemotherapy, radiotherapy and pelvic surgery can lead to POF. Infectious Causes; some viral and microbial infections can be followed by POF. Environmental toxins, such as cigarette smoking are reported as risk factors of spontaneous POF. Idiopathic; in most cases, no identifiable etiology can be recognized after complete evaluation. |
format | Online Article Text |
id | pubmed-4059950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-40599502014-06-24 Pathogenesis and Causes of Premature Ovarian Failure: An Update Ebrahimi, Mahbod Akbari Asbagh, Firoozeh Int J Fertil Steril Review Article Genetic disorders, which could involve the X chromosome or autosomes. However, the growing body of literature demonstrates a list of newly discovered mutations that may be responsible for causing POF. Most of these mutations are extremely rare, and most cases of POF are still considered to be idiopathic. Autoimmune causes; there is some evidence of an association of POF with lymphocytic oophoritis and other autoimmune disorders. Antiovarian antibodies are reported in POF, but their specificity and pathogenic role are obscure. Iatrogenic causes; chemotherapy, radiotherapy and pelvic surgery can lead to POF. Infectious Causes; some viral and microbial infections can be followed by POF. Environmental toxins, such as cigarette smoking are reported as risk factors of spontaneous POF. Idiopathic; in most cases, no identifiable etiology can be recognized after complete evaluation. Royan Institute 2011 2011-09-23 /pmc/articles/PMC4059950/ /pubmed/24963360 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ebrahimi, Mahbod Akbari Asbagh, Firoozeh Pathogenesis and Causes of Premature Ovarian Failure: An Update |
title | Pathogenesis and Causes of Premature Ovarian Failure: An Update |
title_full | Pathogenesis and Causes of Premature Ovarian Failure: An Update |
title_fullStr | Pathogenesis and Causes of Premature Ovarian Failure: An Update |
title_full_unstemmed | Pathogenesis and Causes of Premature Ovarian Failure: An Update |
title_short | Pathogenesis and Causes of Premature Ovarian Failure: An Update |
title_sort | pathogenesis and causes of premature ovarian failure: an update |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059950/ https://www.ncbi.nlm.nih.gov/pubmed/24963360 |
work_keys_str_mv | AT ebrahimimahbod pathogenesisandcausesofprematureovarianfailureanupdate AT akbariasbaghfiroozeh pathogenesisandcausesofprematureovarianfailureanupdate |