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Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial
BACKGROUND: To evaluate the local response according to stability after radiotherapy (RT) with a special focus on quality-of-life (QoL), fatigue, pain and emotional distress in patients with unstable spinal bone metastases. METHODS: In this prospective trial, 30 patients were treated from September...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060071/ https://www.ncbi.nlm.nih.gov/pubmed/24917420 http://dx.doi.org/10.1186/1748-717X-9-133 |
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author | Rief, Harald Heinhold, Maximiliane Bruckner, Thomas Schlampp, Ingmar Förster, Robert Welzel, Thomas Bostel, Tilman Debus, Jürgen Rieken, Stefan |
author_facet | Rief, Harald Heinhold, Maximiliane Bruckner, Thomas Schlampp, Ingmar Förster, Robert Welzel, Thomas Bostel, Tilman Debus, Jürgen Rieken, Stefan |
author_sort | Rief, Harald |
collection | PubMed |
description | BACKGROUND: To evaluate the local response according to stability after radiotherapy (RT) with a special focus on quality-of-life (QoL), fatigue, pain and emotional distress in patients with unstable spinal bone metastases. METHODS: In this prospective trial, 30 patients were treated from September 2011 until March 2013. The stability of osteolytic metastases in the thoracic and lumbar spine was evaluated on the basis of the Taneichi-score after three and six months. EORTC QLQ-BM22, EORTC QLQ-FA13, and QSC-R10 were assessed at baseline, and three months after RT. RESULTS: After 3 months, 25% (n = 6) and after 6 months 33.3% (n = 8) were classified as stable. QoL, fatigue, and emotional distress showed no difference over the course. The pain response 3 months after RT showed a significant difference (p < 0.001). Pathological fractures occurred in 8.3% of the patients (n = 2) within six months following RT. CONCLUSIONS: Our trial demonstrated that RT can improve stability in one third of patients over a 6-months period with unstable spinal metastases. Importantly, for these patients pain relief was detected but RT had no impact on QoL, fatigue, and emotional distress. TRIAL REGISTRATION: Clinical trial identifier NCT01409720. |
format | Online Article Text |
id | pubmed-4060071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40600712014-06-18 Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial Rief, Harald Heinhold, Maximiliane Bruckner, Thomas Schlampp, Ingmar Förster, Robert Welzel, Thomas Bostel, Tilman Debus, Jürgen Rieken, Stefan Radiat Oncol Research BACKGROUND: To evaluate the local response according to stability after radiotherapy (RT) with a special focus on quality-of-life (QoL), fatigue, pain and emotional distress in patients with unstable spinal bone metastases. METHODS: In this prospective trial, 30 patients were treated from September 2011 until March 2013. The stability of osteolytic metastases in the thoracic and lumbar spine was evaluated on the basis of the Taneichi-score after three and six months. EORTC QLQ-BM22, EORTC QLQ-FA13, and QSC-R10 were assessed at baseline, and three months after RT. RESULTS: After 3 months, 25% (n = 6) and after 6 months 33.3% (n = 8) were classified as stable. QoL, fatigue, and emotional distress showed no difference over the course. The pain response 3 months after RT showed a significant difference (p < 0.001). Pathological fractures occurred in 8.3% of the patients (n = 2) within six months following RT. CONCLUSIONS: Our trial demonstrated that RT can improve stability in one third of patients over a 6-months period with unstable spinal metastases. Importantly, for these patients pain relief was detected but RT had no impact on QoL, fatigue, and emotional distress. TRIAL REGISTRATION: Clinical trial identifier NCT01409720. BioMed Central 2014-06-11 /pmc/articles/PMC4060071/ /pubmed/24917420 http://dx.doi.org/10.1186/1748-717X-9-133 Text en Copyright © 2014 Rief et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Rief, Harald Heinhold, Maximiliane Bruckner, Thomas Schlampp, Ingmar Förster, Robert Welzel, Thomas Bostel, Tilman Debus, Jürgen Rieken, Stefan Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
title | Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
title_full | Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
title_fullStr | Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
title_full_unstemmed | Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
title_short | Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
title_sort | quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy - a prospective trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060071/ https://www.ncbi.nlm.nih.gov/pubmed/24917420 http://dx.doi.org/10.1186/1748-717X-9-133 |
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