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Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development

Prostate is a male sex-accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differe...

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Autores principales: Omori, Akiko, Miyagawa, Shinichi, Ogino, Yukiko, Harada, Masayo, Ishii, Kenichiro, Sugimura, Yoshiki, Ogino, Hajime, Nakagata, Naomi, Yamada, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060178/
https://www.ncbi.nlm.nih.gov/pubmed/24731097
http://dx.doi.org/10.1210/en.2013-2054
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author Omori, Akiko
Miyagawa, Shinichi
Ogino, Yukiko
Harada, Masayo
Ishii, Kenichiro
Sugimura, Yoshiki
Ogino, Hajime
Nakagata, Naomi
Yamada, Gen
author_facet Omori, Akiko
Miyagawa, Shinichi
Ogino, Yukiko
Harada, Masayo
Ishii, Kenichiro
Sugimura, Yoshiki
Ogino, Hajime
Nakagata, Naomi
Yamada, Gen
author_sort Omori, Akiko
collection PubMed
description Prostate is a male sex-accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for bone morphogenetic protein (Bmp) signaling. This study shows that Bmp signaling prominently increases during prostatic differentiation in the luminal epithelia, which is monitored by the expression of phosphorylated Smad1/5/8. To elucidate the mechanism of epithelial differentiation and the function of Bmp signaling during prostatic development, conditional male mutant mouse analysis for the epithelial-specific Bmp receptor 1a (Bmpr1a) was performed. We demonstrate that Bmp signaling is indispensable for luminal cell maturation, which regulates basal cell proliferation. Expression of the prostatic epithelial regulatory gene Nkx3.1 was significantly reduced in the Bmpr1a mutants. These results indicate that Bmp signaling is a key factor for prostatic epithelial differentiation, possibly by controlling the prostatic regulatory gene Nkx3.1.
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spelling pubmed-40601782014-10-24 Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development Omori, Akiko Miyagawa, Shinichi Ogino, Yukiko Harada, Masayo Ishii, Kenichiro Sugimura, Yoshiki Ogino, Hajime Nakagata, Naomi Yamada, Gen Endocrinology Growth Factors-Cytokines Prostate is a male sex-accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for bone morphogenetic protein (Bmp) signaling. This study shows that Bmp signaling prominently increases during prostatic differentiation in the luminal epithelia, which is monitored by the expression of phosphorylated Smad1/5/8. To elucidate the mechanism of epithelial differentiation and the function of Bmp signaling during prostatic development, conditional male mutant mouse analysis for the epithelial-specific Bmp receptor 1a (Bmpr1a) was performed. We demonstrate that Bmp signaling is indispensable for luminal cell maturation, which regulates basal cell proliferation. Expression of the prostatic epithelial regulatory gene Nkx3.1 was significantly reduced in the Bmpr1a mutants. These results indicate that Bmp signaling is a key factor for prostatic epithelial differentiation, possibly by controlling the prostatic regulatory gene Nkx3.1. Endocrine Society 2014-07 2014-04-14 /pmc/articles/PMC4060178/ /pubmed/24731097 http://dx.doi.org/10.1210/en.2013-2054 Text en Copyright © 2014 by the Endocrine Society This article has been published under the terms of the Creative Commons Attribution License (CC-BY (http://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the Endocrine Society the exclusive right to publish the article and identify itself as the original publisher.
spellingShingle Growth Factors-Cytokines
Omori, Akiko
Miyagawa, Shinichi
Ogino, Yukiko
Harada, Masayo
Ishii, Kenichiro
Sugimura, Yoshiki
Ogino, Hajime
Nakagata, Naomi
Yamada, Gen
Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development
title Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development
title_full Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development
title_fullStr Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development
title_full_unstemmed Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development
title_short Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development
title_sort essential roles of epithelial bone morphogenetic protein signaling during prostatic development
topic Growth Factors-Cytokines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060178/
https://www.ncbi.nlm.nih.gov/pubmed/24731097
http://dx.doi.org/10.1210/en.2013-2054
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