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Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure
We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic dysfunction. The observation that VEGF-A induces a “brown adipose tissue (BAT)-like” phenotype in WAT prompted us to further explore the direct function of VEGF-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060212/ https://www.ncbi.nlm.nih.gov/pubmed/24944907 http://dx.doi.org/10.1016/j.molmet.2014.03.010 |
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author | Sun, Kai Kusminski, Christine M. Luby-Phelps, Kate Spurgin, Stephen B. An, Yu A. Wang, Qiong A. Holland, William L. Scherer, Philipp E. |
author_facet | Sun, Kai Kusminski, Christine M. Luby-Phelps, Kate Spurgin, Stephen B. An, Yu A. Wang, Qiong A. Holland, William L. Scherer, Philipp E. |
author_sort | Sun, Kai |
collection | PubMed |
description | We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic dysfunction. The observation that VEGF-A induces a “brown adipose tissue (BAT)-like” phenotype in WAT prompted us to further explore the direct function of VEGF-A in BAT. We utilized a doxycycline (Dox)-inducible, brown adipocyte-specific VEGF-A transgenic overexpression model to assess direct effects of VEGF-A in BAT in vivo. We observed that BAT-specific VEGF-A expression increases vascularization and up-regulates expression of both UCP1 and PGC-1α in BAT. As a result, the transgenic mice show increased thermogenesis during chronic cold exposure. In diet-induced obese mice, introducing VEGF-A locally in BAT rescues capillary rarefaction, ameliorates brown adipocyte dysfunction, and improves deleterious effects on glucose and lipid metabolism caused by a high-fat diet challenge. These results demonstrate a direct positive role of VEGF-A in the activation and expansion of BAT. |
format | Online Article Text |
id | pubmed-4060212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-40602122014-06-18 Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure Sun, Kai Kusminski, Christine M. Luby-Phelps, Kate Spurgin, Stephen B. An, Yu A. Wang, Qiong A. Holland, William L. Scherer, Philipp E. Mol Metab Brief Communication We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic dysfunction. The observation that VEGF-A induces a “brown adipose tissue (BAT)-like” phenotype in WAT prompted us to further explore the direct function of VEGF-A in BAT. We utilized a doxycycline (Dox)-inducible, brown adipocyte-specific VEGF-A transgenic overexpression model to assess direct effects of VEGF-A in BAT in vivo. We observed that BAT-specific VEGF-A expression increases vascularization and up-regulates expression of both UCP1 and PGC-1α in BAT. As a result, the transgenic mice show increased thermogenesis during chronic cold exposure. In diet-induced obese mice, introducing VEGF-A locally in BAT rescues capillary rarefaction, ameliorates brown adipocyte dysfunction, and improves deleterious effects on glucose and lipid metabolism caused by a high-fat diet challenge. These results demonstrate a direct positive role of VEGF-A in the activation and expansion of BAT. Elsevier 2014-04-05 /pmc/articles/PMC4060212/ /pubmed/24944907 http://dx.doi.org/10.1016/j.molmet.2014.03.010 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Brief Communication Sun, Kai Kusminski, Christine M. Luby-Phelps, Kate Spurgin, Stephen B. An, Yu A. Wang, Qiong A. Holland, William L. Scherer, Philipp E. Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure |
title | Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure |
title_full | Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure |
title_fullStr | Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure |
title_full_unstemmed | Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure |
title_short | Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure |
title_sort | brown adipose tissue derived vegf-a modulates cold tolerance and energy expenditure |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060212/ https://www.ncbi.nlm.nih.gov/pubmed/24944907 http://dx.doi.org/10.1016/j.molmet.2014.03.010 |
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