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Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs
INTRODUCTION: Currently, there is huge research focus on the development of novel cell-based regeneration and tissue-engineering therapies for the treatment of intervertebral disc degeneration and the associated back pain. Both bone marrow-derived (BM) mesenchymal stem cells (MSCs) and adipose-deriv...
Autores principales: | Clarke, Louise E, McConnell, James C, Sherratt, Michael J, Derby, Brian, Richardson, Stephen M, Hoyland, Judith A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060243/ https://www.ncbi.nlm.nih.gov/pubmed/24618041 http://dx.doi.org/10.1186/ar4505 |
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