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Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

BACKGROUND AND PURPOSE: Stroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients. METHODS: A retrospective...

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Autores principales: Kim, Kwangsoo, Lee, Ji-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Stroke Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060273/
https://www.ncbi.nlm.nih.gov/pubmed/24949315
http://dx.doi.org/10.5853/jos.2014.16.2.91
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author Kim, Kwangsoo
Lee, Ji-Hun
author_facet Kim, Kwangsoo
Lee, Ji-Hun
author_sort Kim, Kwangsoo
collection PubMed
description BACKGROUND AND PURPOSE: Stroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients. METHODS: A retrospective review was conducted in cancer patients with ischemic stroke who were admitted to a general hospital in Busan, Korea, between January 2003 and December 2012. The risk factors and biomarkers for stroke and stroke subtypes in cancer patients were compared with age- and sex-matched noncancer patients with ischemic stroke who were admitted to the same hospital during the same period. RESULTS: One hundred fifty-six cancer patients with ischemic stroke were identified. Cancer patients with ischemic stroke were found to have a significantly lower proportion of hypertension, atrial fibrillation, hyperlipidemia, and ischemic heart disease than noncancer patients with ischemic stroke. However, stroke biomarkers, such as erythrocyte sedimentation rate and high-sensitivity C-reactive protein, fibrinogen, pro-brain natriuretic peptide, and D-dimer levels, were significantly increased in cancer patients with ischemic stroke than in noncancer patients. Large-artery atherosclerosis and stroke of undetermined cause were more common in cancer patients with ischemic stroke than in noncancer patients with ischemic stroke. CONCLUSIONS: Cancer patients with ischemic stroke showed different risk factors, stroke biomarkers, and stroke etiology compared with noncancer patients with ischemic stroke.
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spelling pubmed-40602732014-06-19 Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients Kim, Kwangsoo Lee, Ji-Hun J Stroke Original Article BACKGROUND AND PURPOSE: Stroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients. METHODS: A retrospective review was conducted in cancer patients with ischemic stroke who were admitted to a general hospital in Busan, Korea, between January 2003 and December 2012. The risk factors and biomarkers for stroke and stroke subtypes in cancer patients were compared with age- and sex-matched noncancer patients with ischemic stroke who were admitted to the same hospital during the same period. RESULTS: One hundred fifty-six cancer patients with ischemic stroke were identified. Cancer patients with ischemic stroke were found to have a significantly lower proportion of hypertension, atrial fibrillation, hyperlipidemia, and ischemic heart disease than noncancer patients with ischemic stroke. However, stroke biomarkers, such as erythrocyte sedimentation rate and high-sensitivity C-reactive protein, fibrinogen, pro-brain natriuretic peptide, and D-dimer levels, were significantly increased in cancer patients with ischemic stroke than in noncancer patients. Large-artery atherosclerosis and stroke of undetermined cause were more common in cancer patients with ischemic stroke than in noncancer patients with ischemic stroke. CONCLUSIONS: Cancer patients with ischemic stroke showed different risk factors, stroke biomarkers, and stroke etiology compared with noncancer patients with ischemic stroke. Korean Stroke Society 2014-05 2014-05-30 /pmc/articles/PMC4060273/ /pubmed/24949315 http://dx.doi.org/10.5853/jos.2014.16.2.91 Text en Copyright © 2014 Korean Stroke Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Kwangsoo
Lee, Ji-Hun
Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients
title Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients
title_full Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients
title_fullStr Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients
title_full_unstemmed Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients
title_short Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients
title_sort risk factors and biomarkers of ischemic stroke in cancer patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060273/
https://www.ncbi.nlm.nih.gov/pubmed/24949315
http://dx.doi.org/10.5853/jos.2014.16.2.91
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