Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases

INTRODUCTION: The majority of the genetic variance of systemic lupus erythematosus (SLE) remains unexplained by the common disease-common variant hypothesis. Rare variants, which are not detectable by genome-wide association studies because of their low frequencies, are predicted to explain part of...

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Detalles Bibliográficos
Autores principales: Roberts, Amy L, Thomas, Ellen RA, Bhosle, Shriram, Game, Laurence, Obraztsova, Olga, Aitman, Timothy J, Vyse, Timothy J, Rhodes, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060450/
https://www.ncbi.nlm.nih.gov/pubmed/24886912
http://dx.doi.org/10.1186/ar4566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060450/
https://www.ncbi.nlm.nih.gov/pubmed/24886912
http://dx.doi.org/10.1186/ar4566

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