Presynaptic mechanisms of neuronal plasticity and their role in epilepsy

Synaptic communication requires constant adjustments of pre- and postsynaptic efficacies. In addition to synaptic long term plasticity, the presynaptic machinery underlies homeostatic regulations which prevent out of range transmitter release. In this minireview we will discuss the relevance of sele...

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Detalles Bibliográficos
Autores principales: Meier, Jochen C., Semtner, Marcus, Winkelmann, Aline, Wolfart, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060558/
https://www.ncbi.nlm.nih.gov/pubmed/24987332
http://dx.doi.org/10.3389/fncel.2014.00164
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author Meier, Jochen C.
Semtner, Marcus
Winkelmann, Aline
Wolfart, Jakob
author_facet Meier, Jochen C.
Semtner, Marcus
Winkelmann, Aline
Wolfart, Jakob
author_sort Meier, Jochen C.
collection PubMed
description Synaptic communication requires constant adjustments of pre- and postsynaptic efficacies. In addition to synaptic long term plasticity, the presynaptic machinery underlies homeostatic regulations which prevent out of range transmitter release. In this minireview we will discuss the relevance of selected presynaptic mechanisms to epilepsy including voltage- and ligand-gated ion channels as well as cannabinoid and adenosine receptor signaling.
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spelling pubmed-40605582014-07-01 Presynaptic mechanisms of neuronal plasticity and their role in epilepsy Meier, Jochen C. Semtner, Marcus Winkelmann, Aline Wolfart, Jakob Front Cell Neurosci Neuroscience Synaptic communication requires constant adjustments of pre- and postsynaptic efficacies. In addition to synaptic long term plasticity, the presynaptic machinery underlies homeostatic regulations which prevent out of range transmitter release. In this minireview we will discuss the relevance of selected presynaptic mechanisms to epilepsy including voltage- and ligand-gated ion channels as well as cannabinoid and adenosine receptor signaling. Frontiers Media S.A. 2014-06-17 /pmc/articles/PMC4060558/ /pubmed/24987332 http://dx.doi.org/10.3389/fncel.2014.00164 Text en Copyright © 2014 Meier, Semtner, Winkelmann and Wolfart. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Meier, Jochen C.
Semtner, Marcus
Winkelmann, Aline
Wolfart, Jakob
Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
title Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
title_full Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
title_fullStr Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
title_full_unstemmed Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
title_short Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
title_sort presynaptic mechanisms of neuronal plasticity and their role in epilepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060558/
https://www.ncbi.nlm.nih.gov/pubmed/24987332
http://dx.doi.org/10.3389/fncel.2014.00164
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