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Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders
In the present study, we examined the therapeutic effects of olmesartan, an angiotensin II (Ang II) type 1 receptor (AT1R)-specific blocker, in genetically obese diabetic KKAy mice, a model of human metabolic disorders with visceral obesity, with a focus on an olmesartan effect on the adipose tissue...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060760/ https://www.ncbi.nlm.nih.gov/pubmed/24991574 http://dx.doi.org/10.1155/2014/946492 |
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author | Maeda, Akinobu Tamura, Kouichi Wakui, Hiromichi Ohsawa, Masato Azushima, Kengo Uneda, Kazushi Kanaoka, Tomohiko Kobayashi, Ryu Ohki, Kohji Matsuda, Miyuki Tsurumi-Ikeya, Yuko Yamashita, Akio Tokita, Yasuo Umemura, Satoshi |
author_facet | Maeda, Akinobu Tamura, Kouichi Wakui, Hiromichi Ohsawa, Masato Azushima, Kengo Uneda, Kazushi Kanaoka, Tomohiko Kobayashi, Ryu Ohki, Kohji Matsuda, Miyuki Tsurumi-Ikeya, Yuko Yamashita, Akio Tokita, Yasuo Umemura, Satoshi |
author_sort | Maeda, Akinobu |
collection | PubMed |
description | In the present study, we examined the therapeutic effects of olmesartan, an angiotensin II (Ang II) type 1 receptor (AT1R)-specific blocker, in genetically obese diabetic KKAy mice, a model of human metabolic disorders with visceral obesity, with a focus on an olmesartan effect on the adipose tissue. Olmesartan treatment (3 mg/kg per day) for 4 weeks significantly lowered systolic blood pressure but did not affect body weight during the study period in KKAy mice. However, there were three interesting findings possibly related to the pleiotropic effects of olmesartan on adipose tissue in KKAy mice: (1) an inhibitory effect on adipocyte hypertrophy, (2) a suppressive effect on IL-6 gene expression, and (3) an ameliorating effect on oxidative stress. On the other hand, olmesartan exerted no evident influence on the adipose tissue expression of AT1R-associated protein (ATRAP), which is a molecule interacting with AT1R so as to inhibit pathological AT1R activation and is suggested to be an emerging molecular target in metabolic disorders with visceral obesity. Collectively, these results suggest that the blood pressure lowering effect of olmesartan in KKAy mice is associated with an improvement in adipocyte, including suppression of adipocyte hypertrophy and inhibition of the adipose IL-6-oxidative stress axis. Further study is needed to clarify the functional role of adipose ATRAP in the pleiotropic effects of olmesartan. |
format | Online Article Text |
id | pubmed-4060760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40607602014-07-02 Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders Maeda, Akinobu Tamura, Kouichi Wakui, Hiromichi Ohsawa, Masato Azushima, Kengo Uneda, Kazushi Kanaoka, Tomohiko Kobayashi, Ryu Ohki, Kohji Matsuda, Miyuki Tsurumi-Ikeya, Yuko Yamashita, Akio Tokita, Yasuo Umemura, Satoshi Biomed Res Int Research Article In the present study, we examined the therapeutic effects of olmesartan, an angiotensin II (Ang II) type 1 receptor (AT1R)-specific blocker, in genetically obese diabetic KKAy mice, a model of human metabolic disorders with visceral obesity, with a focus on an olmesartan effect on the adipose tissue. Olmesartan treatment (3 mg/kg per day) for 4 weeks significantly lowered systolic blood pressure but did not affect body weight during the study period in KKAy mice. However, there were three interesting findings possibly related to the pleiotropic effects of olmesartan on adipose tissue in KKAy mice: (1) an inhibitory effect on adipocyte hypertrophy, (2) a suppressive effect on IL-6 gene expression, and (3) an ameliorating effect on oxidative stress. On the other hand, olmesartan exerted no evident influence on the adipose tissue expression of AT1R-associated protein (ATRAP), which is a molecule interacting with AT1R so as to inhibit pathological AT1R activation and is suggested to be an emerging molecular target in metabolic disorders with visceral obesity. Collectively, these results suggest that the blood pressure lowering effect of olmesartan in KKAy mice is associated with an improvement in adipocyte, including suppression of adipocyte hypertrophy and inhibition of the adipose IL-6-oxidative stress axis. Further study is needed to clarify the functional role of adipose ATRAP in the pleiotropic effects of olmesartan. Hindawi Publishing Corporation 2014 2014-06-02 /pmc/articles/PMC4060760/ /pubmed/24991574 http://dx.doi.org/10.1155/2014/946492 Text en Copyright © 2014 Akinobu Maeda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Maeda, Akinobu Tamura, Kouichi Wakui, Hiromichi Ohsawa, Masato Azushima, Kengo Uneda, Kazushi Kanaoka, Tomohiko Kobayashi, Ryu Ohki, Kohji Matsuda, Miyuki Tsurumi-Ikeya, Yuko Yamashita, Akio Tokita, Yasuo Umemura, Satoshi Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders |
title | Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders |
title_full | Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders |
title_fullStr | Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders |
title_full_unstemmed | Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders |
title_short | Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders |
title_sort | effects of the angiotensin receptor blocker olmesartan on adipocyte hypertrophy and function in mice with metabolic disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060760/ https://www.ncbi.nlm.nih.gov/pubmed/24991574 http://dx.doi.org/10.1155/2014/946492 |
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