In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines

An in vitro antidiabetic activity on α-amylase and α–glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a–3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, (1)H NMR, (13)C NMR, EI-MS, and single crystal X...

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Detalles Bibliográficos
Autores principales: Bharathi, A., Roopan, Selvaraj Mohana, Vasavi, C. S., Munusami, Punnagai, Gayathri, G. A., Gayathri, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060768/
https://www.ncbi.nlm.nih.gov/pubmed/24991576
http://dx.doi.org/10.1155/2014/971569
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author Bharathi, A.
Roopan, Selvaraj Mohana
Vasavi, C. S.
Munusami, Punnagai
Gayathri, G. A.
Gayathri, M.
author_facet Bharathi, A.
Roopan, Selvaraj Mohana
Vasavi, C. S.
Munusami, Punnagai
Gayathri, G. A.
Gayathri, M.
author_sort Bharathi, A.
collection PubMed
description An in vitro antidiabetic activity on α-amylase and α–glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a–3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, (1)H NMR, (13)C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a–3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α-amylase and α-glucosidase.
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spelling pubmed-40607682014-07-02 In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines Bharathi, A. Roopan, Selvaraj Mohana Vasavi, C. S. Munusami, Punnagai Gayathri, G. A. Gayathri, M. Biomed Res Int Research Article An in vitro antidiabetic activity on α-amylase and α–glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a–3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, (1)H NMR, (13)C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a–3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α-amylase and α-glucosidase. Hindawi Publishing Corporation 2014 2014-06-02 /pmc/articles/PMC4060768/ /pubmed/24991576 http://dx.doi.org/10.1155/2014/971569 Text en Copyright © 2014 A. Bharathi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bharathi, A.
Roopan, Selvaraj Mohana
Vasavi, C. S.
Munusami, Punnagai
Gayathri, G. A.
Gayathri, M.
In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines
title In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines
title_full In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines
title_fullStr In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines
title_full_unstemmed In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines
title_short In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines
title_sort in silico molecular docking and in vitro antidiabetic studies of dihydropyrimido[4,5-a]acridin-2-amines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060768/
https://www.ncbi.nlm.nih.gov/pubmed/24991576
http://dx.doi.org/10.1155/2014/971569
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