The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment

Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentiation is not known. Here we report...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Lee, Yun-Hwa, Jones, Amanda E., Woolnough, Jessica L., Zhou, Dewang, Dai, Qian, Wu, Qiang, Giles, Keith E., Townes, Tim M., Wang, Hengbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060806/
https://www.ncbi.nlm.nih.gov/pubmed/24784029
http://dx.doi.org/10.1038/ncomms4818

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