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Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52

As co-chaperones of Hsp90 (heat-shock protein 90), FKBP51 (FK506-binding protein of 51 kDa) and FKBP52 (FK506-binding protein of 52 kDa) act as antagonists in regulating the hormone affinity and nuclear transport of steroid receptor complexes. Exchange of Leu(119) in FKBP51 for Pro(119) in FKBP52 ha...

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Detalles Bibliográficos
Autores principales:	Mustafi, Sourajit M., LeMaster, David M., Hernández, Griselda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060953/ https://www.ncbi.nlm.nih.gov/pubmed/24749623 http://dx.doi.org/10.1042/BJ20140232

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