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Identifying Emerging Motif in Growing Networks

As function units, network motifs have been detected to reveal evolutionary mechanisms of complex systems, such as biological networks, food webs, engineering networks and social networks. However, emergence of motifs in growing networks may be problematic due to large fluctuation of subgraph freque...

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Detalles Bibliográficos
Autores principales: Shi, Haijia, Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061033/
https://www.ncbi.nlm.nih.gov/pubmed/24936978
http://dx.doi.org/10.1371/journal.pone.0099634
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author Shi, Haijia
Shi, Lei
author_facet Shi, Haijia
Shi, Lei
author_sort Shi, Haijia
collection PubMed
description As function units, network motifs have been detected to reveal evolutionary mechanisms of complex systems, such as biological networks, food webs, engineering networks and social networks. However, emergence of motifs in growing networks may be problematic due to large fluctuation of subgraph frequency in the initial stage. This paper contributes to present a method which can identify the emergence of motif in growing networks. Based on the Erdös-Rényi(E-R) random null model, the variation rate of expected frequency of subgraph at adjacent time points was used to define the suitable detection range for motif identification. Upper and lower boundaries of the range were obtained in analytical form according to a chosen risk level. Then, the statistical metric Z-score was extended to a new one,[Image: see text], which effectively reveals the statistical significance of subgraph in a continuous period of time. In this paper, a novel research framework of motif identification was proposed, defining critical boundaries for the evolutionary process of networks and a significance metric of time scale. Finally, an industrial ecosystem at Kalundborg was adopted as a case study to illustrate the effectiveness and convenience of the proposed methodology.
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spelling pubmed-40610332014-06-20 Identifying Emerging Motif in Growing Networks Shi, Haijia Shi, Lei PLoS One Research Article As function units, network motifs have been detected to reveal evolutionary mechanisms of complex systems, such as biological networks, food webs, engineering networks and social networks. However, emergence of motifs in growing networks may be problematic due to large fluctuation of subgraph frequency in the initial stage. This paper contributes to present a method which can identify the emergence of motif in growing networks. Based on the Erdös-Rényi(E-R) random null model, the variation rate of expected frequency of subgraph at adjacent time points was used to define the suitable detection range for motif identification. Upper and lower boundaries of the range were obtained in analytical form according to a chosen risk level. Then, the statistical metric Z-score was extended to a new one,[Image: see text], which effectively reveals the statistical significance of subgraph in a continuous period of time. In this paper, a novel research framework of motif identification was proposed, defining critical boundaries for the evolutionary process of networks and a significance metric of time scale. Finally, an industrial ecosystem at Kalundborg was adopted as a case study to illustrate the effectiveness and convenience of the proposed methodology. Public Library of Science 2014-06-17 /pmc/articles/PMC4061033/ /pubmed/24936978 http://dx.doi.org/10.1371/journal.pone.0099634 Text en © 2014 Shi, Shi http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Shi, Haijia
Shi, Lei
Identifying Emerging Motif in Growing Networks
title Identifying Emerging Motif in Growing Networks
title_full Identifying Emerging Motif in Growing Networks
title_fullStr Identifying Emerging Motif in Growing Networks
title_full_unstemmed Identifying Emerging Motif in Growing Networks
title_short Identifying Emerging Motif in Growing Networks
title_sort identifying emerging motif in growing networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061033/
https://www.ncbi.nlm.nih.gov/pubmed/24936978
http://dx.doi.org/10.1371/journal.pone.0099634
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