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On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation
BACKGROUND: Protein sequence similarities to any types of non-globular segments (coiled coils, low complexity regions, transmembrane regions, long loops, etc. where either positional sequence conservation is the result of a very simple, physically induced pattern or rather integral sequence properti...
Autores principales: | Wong, Wing-Cheong, Maurer-Stroh, Sebastian, Eisenhaber, Birgit, Eisenhaber, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061105/ https://www.ncbi.nlm.nih.gov/pubmed/24890864 http://dx.doi.org/10.1186/1471-2105-15-166 |
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