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Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system

We have previously demonstrated that voluntary exercise facilitates discrimination learning in a modified T-maze. There is evidence implicating the dorsolateral striatum (DLS) as the substrate for this task. The present experiments examined whether changes in DLS dopamine receptors might underlie th...

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Detalles Bibliográficos
Autores principales: Eddy, Meghan C., Stansfield, Katherine J., Green, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061424/
https://www.ncbi.nlm.nih.gov/pubmed/24934332
http://dx.doi.org/10.1101/lm.034462.114
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author Eddy, Meghan C.
Stansfield, Katherine J.
Green, John T.
author_facet Eddy, Meghan C.
Stansfield, Katherine J.
Green, John T.
author_sort Eddy, Meghan C.
collection PubMed
description We have previously demonstrated that voluntary exercise facilitates discrimination learning in a modified T-maze. There is evidence implicating the dorsolateral striatum (DLS) as the substrate for this task. The present experiments examined whether changes in DLS dopamine receptors might underlie the exercise-associated facilitation. Infusing a D1R antagonist into the DLS prior to discrimination learning facilitated the performance of nonexercising rats but not exercising rats. Infusing a D2R antagonist impaired the performance of exercising rats but not nonexercising rats. Exercise-associated facilitation of this task may rely on an exercise-induced decrease in D1R and increase in D2R activation in the DLS.
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spelling pubmed-40614242015-07-01 Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system Eddy, Meghan C. Stansfield, Katherine J. Green, John T. Learn Mem Brief Communication We have previously demonstrated that voluntary exercise facilitates discrimination learning in a modified T-maze. There is evidence implicating the dorsolateral striatum (DLS) as the substrate for this task. The present experiments examined whether changes in DLS dopamine receptors might underlie the exercise-associated facilitation. Infusing a D1R antagonist into the DLS prior to discrimination learning facilitated the performance of nonexercising rats but not exercising rats. Infusing a D2R antagonist impaired the performance of exercising rats but not nonexercising rats. Exercise-associated facilitation of this task may rely on an exercise-induced decrease in D1R and increase in D2R activation in the DLS. Cold Spring Harbor Laboratory Press 2014-07 /pmc/articles/PMC4061424/ /pubmed/24934332 http://dx.doi.org/10.1101/lm.034462.114 Text en © 2014 Eddy et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Eddy, Meghan C.
Stansfield, Katherine J.
Green, John T.
Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
title Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
title_full Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
title_fullStr Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
title_full_unstemmed Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
title_short Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
title_sort voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061424/
https://www.ncbi.nlm.nih.gov/pubmed/24934332
http://dx.doi.org/10.1101/lm.034462.114
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