An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial

BACKGROUND: Organ dysfunction consequent to infection (‘severe sepsis’) is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated to have potentially beneficial effects on orga...

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Detalles Bibliográficos
Autores principales: Orme, Robert M L’E, Perkins, Gavin D, McAuley, Daniel F, Liu, Kathleen D, Mason, Alexina J, Morelli, Andrea, Singer, Mervyn, Ashby, Deborah, Gordon, Anthony C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061524/
https://www.ncbi.nlm.nih.gov/pubmed/24894386
http://dx.doi.org/10.1186/1745-6215-15-199

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