Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial

BACKGROUND: Early-onset dementia is common in Down syndrome adults, who have trisomy 21. The amyloid precursor protein gene is on chromosome 21, and so is over-expressed in Down syndrome, leading to amyloid β (Aβ) over-production, a major upstream pathway leading to Alzheimer disease (AD). Statins (...

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Detalles Bibliográficos
Autores principales: Cooper, Sally-Ann, Caslake, Muriel, Evans, Jonathan, Hassiotis, Angela, Jahoda, Andrew, McConnachie, Alex, Morrison, Jill, Ring, Howard, Starr, John, Stiles, Ciara, Sullivan, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061534/
https://www.ncbi.nlm.nih.gov/pubmed/24888381
http://dx.doi.org/10.1186/1745-6215-15-202

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