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Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis

Reactive oxygen species (ROS) have been implemented in the etiology of pulmonary fibrosis (PF) in systemic sclerosis. In the bleomycin model, we evaluated the role of acquired mutations in mitochondrial DNA (mtDNA) and respiratory chain defects as a trigger of ROS formation and fibrogenesis. Adult m...

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Detalles Bibliográficos
Autores principales:	Gazdhar, Amiq, Lebrecht, Dirk, Roth, Michael, Tamm, Michael, Venhoff, Nils, Foocharoen, Chingching, Geiser, Thomas, Walker, Ulrich A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061543/ https://www.ncbi.nlm.nih.gov/pubmed/24939573 http://dx.doi.org/10.1038/srep05336

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