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Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study
BACKGROUND: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients. TYPE OF STUDY: Matched case control type of longitudinal study was conducted in 2006–2007. MATERIALS AND METHODS: Two medical retina specialists examined the eyes having an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061665/ https://www.ncbi.nlm.nih.gov/pubmed/23619502 http://dx.doi.org/10.4103/0301-4738.111213 |
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author | Al Wadani, Fahad Khandekar, Rajiv Salim, Gigani Al Ali, Mohammed Ramzi, Salman |
author_facet | Al Wadani, Fahad Khandekar, Rajiv Salim, Gigani Al Ali, Mohammed Ramzi, Salman |
author_sort | Al Wadani, Fahad |
collection | PubMed |
description | BACKGROUND: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients. TYPE OF STUDY: Matched case control type of longitudinal study was conducted in 2006–2007. MATERIALS AND METHODS: Two medical retina specialists examined the eyes having an event of RVO in the last 15 days. A similar number of eyes without RVO were also examined. The serum and urine homocysteine levels of these persons were tested. Matched pair analysis was carried out to determine the risk of RVO among those with hyperhomocysteinemia. RESULTS: We included 20 cases of RVO and 20 age- and sex-matched persons without RVO. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval 16.60–47(.) 86), P = 2.1 × 10(−13)]. The mean urine homocysteine level among cases and controls was not statistically significant. There were 12 persons with hypertension in both cases and control groups. CONCLUSION: Hyperhomocysteinemia is a risk factor for RVO. Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels. |
format | Online Article Text |
id | pubmed-4061665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40616652014-06-19 Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study Al Wadani, Fahad Khandekar, Rajiv Salim, Gigani Al Ali, Mohammed Ramzi, Salman Indian J Ophthalmol Original Article BACKGROUND: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients. TYPE OF STUDY: Matched case control type of longitudinal study was conducted in 2006–2007. MATERIALS AND METHODS: Two medical retina specialists examined the eyes having an event of RVO in the last 15 days. A similar number of eyes without RVO were also examined. The serum and urine homocysteine levels of these persons were tested. Matched pair analysis was carried out to determine the risk of RVO among those with hyperhomocysteinemia. RESULTS: We included 20 cases of RVO and 20 age- and sex-matched persons without RVO. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval 16.60–47(.) 86), P = 2.1 × 10(−13)]. The mean urine homocysteine level among cases and controls was not statistically significant. There were 12 persons with hypertension in both cases and control groups. CONCLUSION: Hyperhomocysteinemia is a risk factor for RVO. Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels. Medknow Publications & Media Pvt Ltd 2014-03 /pmc/articles/PMC4061665/ /pubmed/23619502 http://dx.doi.org/10.4103/0301-4738.111213 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al Wadani, Fahad Khandekar, Rajiv Salim, Gigani Al Ali, Mohammed Ramzi, Salman Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study |
title | Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study |
title_full | Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study |
title_fullStr | Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study |
title_full_unstemmed | Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study |
title_short | Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study |
title_sort | hyperhomocysteinia is a risk factor for retinal venous occlusion: a case control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061665/ https://www.ncbi.nlm.nih.gov/pubmed/23619502 http://dx.doi.org/10.4103/0301-4738.111213 |
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