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Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy
PURPOSE: To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders. MATERIALS AND METHODS: mfVEP was...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061667/ https://www.ncbi.nlm.nih.gov/pubmed/24088641 http://dx.doi.org/10.4103/0301-4738.118452 |
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author | Jayaraman, Manju Gandhi, Rashmin Anilkumar Ravi, Priya Sen, Parveen |
author_facet | Jayaraman, Manju Gandhi, Rashmin Anilkumar Ravi, Priya Sen, Parveen |
author_sort | Jayaraman, Manju |
collection | PubMed |
description | PURPOSE: To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders. MATERIALS AND METHODS: mfVEP was recorded for 71 eyes of controls and 48 eyes of optic nerve disorders with subgroups of optic neuritis (ON, n = 21 eyes), ischemic optic neuropathy (ION, n = 14 eyes), and compressive optic neuropathy (CON, n = 13 eyes). The size of defect in mfVEP amplitude probability plots and relative latency plots were analyzed. The pattern of the defect in amplitude probability plot was classified according to the visual field profile of optic neuritis treatment trail (ONTT). RESULTS: Median of mfVEP amplitude (log SNR) averaged across 60 sectors were reduced in ON (0.17 (0.13-0.33)), ION (0.14 (0.12-0.21)) and CON (0.21 (0.14-0.30)) when compared to controls. The median mfVEP relative latencies compared to controls were significantly prolonged in ON and CON group of 10.53 (2.62-15.50) ms and 5.73 (2.67-14.14) ms respectively compared to ION group (2.06 (-4.09-13.02)). The common mfVEP amplitude defects observed in probability plots were diffuse pattern in ON, inferior altitudinal defect in ION and temporal hemianopia in CON eyes. CONCLUSIONS: Optic nerve disorders cause reduction in mfVEP amplitudes. The extent of delayed latency noted in ischemic optic neuropathy was significantly lesser compared to subjects with optic neuritis and compressive optic neuropathy. mfVEP amplitudes can be used to objectively assess the topography of the visual field defect. |
format | Online Article Text |
id | pubmed-4061667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40616672014-06-19 Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy Jayaraman, Manju Gandhi, Rashmin Anilkumar Ravi, Priya Sen, Parveen Indian J Ophthalmol Original Article PURPOSE: To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders. MATERIALS AND METHODS: mfVEP was recorded for 71 eyes of controls and 48 eyes of optic nerve disorders with subgroups of optic neuritis (ON, n = 21 eyes), ischemic optic neuropathy (ION, n = 14 eyes), and compressive optic neuropathy (CON, n = 13 eyes). The size of defect in mfVEP amplitude probability plots and relative latency plots were analyzed. The pattern of the defect in amplitude probability plot was classified according to the visual field profile of optic neuritis treatment trail (ONTT). RESULTS: Median of mfVEP amplitude (log SNR) averaged across 60 sectors were reduced in ON (0.17 (0.13-0.33)), ION (0.14 (0.12-0.21)) and CON (0.21 (0.14-0.30)) when compared to controls. The median mfVEP relative latencies compared to controls were significantly prolonged in ON and CON group of 10.53 (2.62-15.50) ms and 5.73 (2.67-14.14) ms respectively compared to ION group (2.06 (-4.09-13.02)). The common mfVEP amplitude defects observed in probability plots were diffuse pattern in ON, inferior altitudinal defect in ION and temporal hemianopia in CON eyes. CONCLUSIONS: Optic nerve disorders cause reduction in mfVEP amplitudes. The extent of delayed latency noted in ischemic optic neuropathy was significantly lesser compared to subjects with optic neuritis and compressive optic neuropathy. mfVEP amplitudes can be used to objectively assess the topography of the visual field defect. Medknow Publications & Media Pvt Ltd 2014-03 /pmc/articles/PMC4061667/ /pubmed/24088641 http://dx.doi.org/10.4103/0301-4738.118452 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jayaraman, Manju Gandhi, Rashmin Anilkumar Ravi, Priya Sen, Parveen Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
title | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
title_full | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
title_fullStr | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
title_full_unstemmed | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
title_short | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
title_sort | multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061667/ https://www.ncbi.nlm.nih.gov/pubmed/24088641 http://dx.doi.org/10.4103/0301-4738.118452 |
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