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The Role of Substance P in Ischaemic Brain Injury

Stroke is a leading cause of death, disability and dementia worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients, meaning that death, severe disability and the requirement for long-term rehabilitation are common outcomes. Cell loss and...

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Detalles Bibliográficos
Autores principales: Turner, Renée J., Vink, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061838/
https://www.ncbi.nlm.nih.gov/pubmed/24961310
http://dx.doi.org/10.3390/brainsci3010123
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author Turner, Renée J.
Vink, Robert
author_facet Turner, Renée J.
Vink, Robert
author_sort Turner, Renée J.
collection PubMed
description Stroke is a leading cause of death, disability and dementia worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients, meaning that death, severe disability and the requirement for long-term rehabilitation are common outcomes. Cell loss and tissue injury following stroke occurs through a number of diverse secondary injury pathways, whose delayed nature provides an opportunity for pharmacological intervention. Amongst these secondary injury factors, increased blood-brain barrier permeability and cerebral oedema are well-documented complications of cerebral ischaemia, whose severity has been shown to be associated with final outcome. Whilst the mechanisms of increased blood-brain barrier permeability and cerebral oedema are largely unknown, recent evidence suggests that the neuropeptide substance P (SP) plays a central role. The aim of this review is to examine the role of SP in ischaemic stroke and report on the potential utility of NK1 tachykinin receptor antagonists as therapeutic agents.
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spelling pubmed-40618382014-06-19 The Role of Substance P in Ischaemic Brain Injury Turner, Renée J. Vink, Robert Brain Sci Review Stroke is a leading cause of death, disability and dementia worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients, meaning that death, severe disability and the requirement for long-term rehabilitation are common outcomes. Cell loss and tissue injury following stroke occurs through a number of diverse secondary injury pathways, whose delayed nature provides an opportunity for pharmacological intervention. Amongst these secondary injury factors, increased blood-brain barrier permeability and cerebral oedema are well-documented complications of cerebral ischaemia, whose severity has been shown to be associated with final outcome. Whilst the mechanisms of increased blood-brain barrier permeability and cerebral oedema are largely unknown, recent evidence suggests that the neuropeptide substance P (SP) plays a central role. The aim of this review is to examine the role of SP in ischaemic stroke and report on the potential utility of NK1 tachykinin receptor antagonists as therapeutic agents. MDPI 2013-01-30 /pmc/articles/PMC4061838/ /pubmed/24961310 http://dx.doi.org/10.3390/brainsci3010123 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Turner, Renée J.
Vink, Robert
The Role of Substance P in Ischaemic Brain Injury
title The Role of Substance P in Ischaemic Brain Injury
title_full The Role of Substance P in Ischaemic Brain Injury
title_fullStr The Role of Substance P in Ischaemic Brain Injury
title_full_unstemmed The Role of Substance P in Ischaemic Brain Injury
title_short The Role of Substance P in Ischaemic Brain Injury
title_sort role of substance p in ischaemic brain injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061838/
https://www.ncbi.nlm.nih.gov/pubmed/24961310
http://dx.doi.org/10.3390/brainsci3010123
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