Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using whole-exome sequencing and targeted sequencing of 10 microRNA (miRNA)-processing genes. A recurrent mutation (E1147K) affecti...

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Detalles Bibliográficos
Autores principales: Torrezan, Giovana T., Ferreira, Elisa N., Nakahata, Adriana M., Barros, Bruna D. F., Castro, Mayra T. M., Correa, Bruna R., Krepischi, Ana C. V., Olivieri, Eloisa H. R., Cunha, Isabela W., Tabori, Uri, Grundy, Paul E., Costa, Cecilia M. L., de Camargo, Beatriz, Galante, Pedro A. F., Carraro, Dirce M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062040/
https://www.ncbi.nlm.nih.gov/pubmed/24909261
http://dx.doi.org/10.1038/ncomms5039

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