Why epistasis is important for tackling complex human disease genetics

EDITORIAL SUMMARY: Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex di...

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Detalles Bibliográficos
Autores principales: Mackay, Trudy FC, Moore, Jason H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062066/
https://www.ncbi.nlm.nih.gov/pubmed/25031624
http://dx.doi.org/10.1186/gm561
Descripción
Sumario:EDITORIAL SUMMARY: Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease.

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