Why epistasis is important for tackling complex human disease genetics

EDITORIAL SUMMARY: Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex di...

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Detalles Bibliográficos
Autores principales: Mackay, Trudy FC, Moore, Jason H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062066/
https://www.ncbi.nlm.nih.gov/pubmed/25031624
http://dx.doi.org/10.1186/gm561
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author Mackay, Trudy FC
Moore, Jason H
author_facet Mackay, Trudy FC
Moore, Jason H
author_sort Mackay, Trudy FC
collection PubMed
description EDITORIAL SUMMARY: Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease.
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spelling pubmed-40620662015-06-09 Why epistasis is important for tackling complex human disease genetics Mackay, Trudy FC Moore, Jason H Genome Med Comment EDITORIAL SUMMARY: Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease. BioMed Central 2014-06-09 /pmc/articles/PMC4062066/ /pubmed/25031624 http://dx.doi.org/10.1186/gm561 Text en Copyright © 2014 Mackay and Moore; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Mackay, Trudy FC
Moore, Jason H
Why epistasis is important for tackling complex human disease genetics
title Why epistasis is important for tackling complex human disease genetics
title_full Why epistasis is important for tackling complex human disease genetics
title_fullStr Why epistasis is important for tackling complex human disease genetics
title_full_unstemmed Why epistasis is important for tackling complex human disease genetics
title_short Why epistasis is important for tackling complex human disease genetics
title_sort why epistasis is important for tackling complex human disease genetics
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062066/
https://www.ncbi.nlm.nih.gov/pubmed/25031624
http://dx.doi.org/10.1186/gm561
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