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In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis

BACKGROUND: Alpha-synuclein (ASYN) is central in Parkinson’s disease (PD) pathogenesis. Converging pieces of evidence suggest that the levels of ASYN expression play a critical role in both familial and sporadic Parkinson’s disease. ASYN fibrils are the main component of inclusions called Lewy Bodie...

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Detalles Bibliográficos
Autores principales:	Ouzounoglou, Eleftherios, Kalamatianos, Dimitrios, Emmanouilidou, Evangelia, Xilouri, Maria, Stefanis, Leonidas, Vekrellis, Kostas, Manolakos, Elias S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062111/ https://www.ncbi.nlm.nih.gov/pubmed/24885905 http://dx.doi.org/10.1186/1752-0509-8-54

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