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Features of the Onset of Takayasu's Arteritis According to Gender

BACKGROUND: Although there are various published epidemiological studies regarding Takayasu's arteritis (TA), none have analyzed the influence of gender on the clinical and laboratory manifestations or vascular alterations at disease onset. OBJECTIVES: To analyze the influence of gender on clin...

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Autores principales: Mont'Alverne, Andrea Rocha de Saboia, de Paula, Luiz Eduardo, Shinjo, Samuel Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062373/
https://www.ncbi.nlm.nih.gov/pubmed/23979780
http://dx.doi.org/10.5935/abc.20130180
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author Mont'Alverne, Andrea Rocha de Saboia
de Paula, Luiz Eduardo
Shinjo, Samuel Katsuyuki
author_facet Mont'Alverne, Andrea Rocha de Saboia
de Paula, Luiz Eduardo
Shinjo, Samuel Katsuyuki
author_sort Mont'Alverne, Andrea Rocha de Saboia
collection PubMed
description BACKGROUND: Although there are various published epidemiological studies regarding Takayasu's arteritis (TA), none have analyzed the influence of gender on the clinical and laboratory manifestations or vascular alterations at disease onset. OBJECTIVES: To analyze the influence of gender on clinical and laboratory manifestations and variations in vascular imaging at TA onset. METHODS: A retrospective, unicentric cohort study that evaluated 55 consecutive TA patients between 1982 and 2012. All available clinical data and laboratory test results related to the onset of the disease were analyzed. We included only patients aged 12-35 years at diagnosis to exclude age-related factors. RESULTS: We analyzed 17 men and 38 women, mostly Caucasian, with a comparable mean age between genders. There was no gender difference regarding the clinical or laboratory characteristics, comorbidities, or smoking habit, except for abdominal pain, which was more common in men. Regarding vascular lesions, the presence of ascending aortic aneurysms was significantly more frequent in males. Male gender represented an independent risk factor for the occurrence of abdominal pain and ascending aortic aneurysms in TA patients. CONCLUSION: Abdominal pain and ascending aortic aneurysms occurred more frequently in men with TA, suggesting a more severe disease profile in males.
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spelling pubmed-40623732014-06-19 Features of the Onset of Takayasu's Arteritis According to Gender Mont'Alverne, Andrea Rocha de Saboia de Paula, Luiz Eduardo Shinjo, Samuel Katsuyuki Arq Bras Cardiol Original Articles BACKGROUND: Although there are various published epidemiological studies regarding Takayasu's arteritis (TA), none have analyzed the influence of gender on the clinical and laboratory manifestations or vascular alterations at disease onset. OBJECTIVES: To analyze the influence of gender on clinical and laboratory manifestations and variations in vascular imaging at TA onset. METHODS: A retrospective, unicentric cohort study that evaluated 55 consecutive TA patients between 1982 and 2012. All available clinical data and laboratory test results related to the onset of the disease were analyzed. We included only patients aged 12-35 years at diagnosis to exclude age-related factors. RESULTS: We analyzed 17 men and 38 women, mostly Caucasian, with a comparable mean age between genders. There was no gender difference regarding the clinical or laboratory characteristics, comorbidities, or smoking habit, except for abdominal pain, which was more common in men. Regarding vascular lesions, the presence of ascending aortic aneurysms was significantly more frequent in males. Male gender represented an independent risk factor for the occurrence of abdominal pain and ascending aortic aneurysms in TA patients. CONCLUSION: Abdominal pain and ascending aortic aneurysms occurred more frequently in men with TA, suggesting a more severe disease profile in males. Sociedade Brasileira de Cardiologia 2013-10 /pmc/articles/PMC4062373/ /pubmed/23979780 http://dx.doi.org/10.5935/abc.20130180 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mont'Alverne, Andrea Rocha de Saboia
de Paula, Luiz Eduardo
Shinjo, Samuel Katsuyuki
Features of the Onset of Takayasu's Arteritis According to Gender
title Features of the Onset of Takayasu's Arteritis According to Gender
title_full Features of the Onset of Takayasu's Arteritis According to Gender
title_fullStr Features of the Onset of Takayasu's Arteritis According to Gender
title_full_unstemmed Features of the Onset of Takayasu's Arteritis According to Gender
title_short Features of the Onset of Takayasu's Arteritis According to Gender
title_sort features of the onset of takayasu's arteritis according to gender
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062373/
https://www.ncbi.nlm.nih.gov/pubmed/23979780
http://dx.doi.org/10.5935/abc.20130180
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