PIP(2) regulates psychostimulant behaviors through its interaction with a membrane protein

Phosphatidylinositol (4,5)-bisphosphate (PIP(2)) regulates the function of ion channels and transporters. Here, we demonstrate that PIP(2) directly binds the human dopamine (DA) transporter (hDAT), a key regulator of DA homeostasis and a target of the psychostimulant amphetamine (AMPH). This binding...

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Detalles Bibliográficos
Autores principales: Hamilton, Peter J., Belovich, Andrea N., Khelashvili, George, Saunders, Christine, Erreger, Kevin, Javitch, Jonathan A., Sitte, Harald H., Weinstein, Harel, Matthies, Heinrich J.G., Galli, Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062427/
https://www.ncbi.nlm.nih.gov/pubmed/24880859
http://dx.doi.org/10.1038/nchembio.1545

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