Mutant Ubiquitin UBB+1 Induces Mitochondrial Fusion by Destabilizing Mitochondrial Fission-Specific Proteins and Confers Resistance to Oxidative Stress-Induced Cell Death in Astrocytic Cells

Mutant ubiquitin UBB+1 is observed in a variety of aging-related neurodegenerative diseases and acts as a potent inhibitor of the ubiquitin proteasome system (UPS). In the present study, we investigated the relationship between impaired UPS (using ectopic expression of UBB+1) and mitochondrial dynam...

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Detalles Bibliográficos
Autores principales: Yim, Nambin, Ryu, Seung-Wook, Han, Eun Chun, Yoon, Jonghee, Choi, Kyungsun, Choi, Chulhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062464/
https://www.ncbi.nlm.nih.gov/pubmed/24941066
http://dx.doi.org/10.1371/journal.pone.0099937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062464/
https://www.ncbi.nlm.nih.gov/pubmed/24941066
http://dx.doi.org/10.1371/journal.pone.0099937

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