A Carbonate-Forming Baeyer-Villiger Monooxygenase

Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase CcsB, which catalyzes the forma...

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Autores principales: Hu, Youcai, Dietrich, David, Xu, Wei, Patel, Ashay, Thuss, Justin A. J., Wang, Jingjing, Yin, Wen-Bing, Qiao, Kangjian, Houk, Kendall N., Vederas, John C., Tang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062580/
https://www.ncbi.nlm.nih.gov/pubmed/24838010
http://dx.doi.org/10.1038/nchembio.1527
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author Hu, Youcai
Dietrich, David
Xu, Wei
Patel, Ashay
Thuss, Justin A. J.
Wang, Jingjing
Yin, Wen-Bing
Qiao, Kangjian
Houk, Kendall N.
Vederas, John C.
Tang, Yi
author_facet Hu, Youcai
Dietrich, David
Xu, Wei
Patel, Ashay
Thuss, Justin A. J.
Wang, Jingjing
Yin, Wen-Bing
Qiao, Kangjian
Houk, Kendall N.
Vederas, John C.
Tang, Yi
author_sort Hu, Youcai
collection PubMed
description Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.
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spelling pubmed-40625802015-01-01 A Carbonate-Forming Baeyer-Villiger Monooxygenase Hu, Youcai Dietrich, David Xu, Wei Patel, Ashay Thuss, Justin A. J. Wang, Jingjing Yin, Wen-Bing Qiao, Kangjian Houk, Kendall N. Vederas, John C. Tang, Yi Nat Chem Biol Article Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates. 2014-05-18 2014-07 /pmc/articles/PMC4062580/ /pubmed/24838010 http://dx.doi.org/10.1038/nchembio.1527 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hu, Youcai
Dietrich, David
Xu, Wei
Patel, Ashay
Thuss, Justin A. J.
Wang, Jingjing
Yin, Wen-Bing
Qiao, Kangjian
Houk, Kendall N.
Vederas, John C.
Tang, Yi
A Carbonate-Forming Baeyer-Villiger Monooxygenase
title A Carbonate-Forming Baeyer-Villiger Monooxygenase
title_full A Carbonate-Forming Baeyer-Villiger Monooxygenase
title_fullStr A Carbonate-Forming Baeyer-Villiger Monooxygenase
title_full_unstemmed A Carbonate-Forming Baeyer-Villiger Monooxygenase
title_short A Carbonate-Forming Baeyer-Villiger Monooxygenase
title_sort carbonate-forming baeyer-villiger monooxygenase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062580/
https://www.ncbi.nlm.nih.gov/pubmed/24838010
http://dx.doi.org/10.1038/nchembio.1527
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