Cargando…

Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation

Transient receptor potential A1 (TRPA1) is implicated in somatosensory processing and pathological pain sensation. Although not strictly voltage-gated, ionic currents of TRPA1 typically rectify outwardly, indicating channel activation at depolarized membrane potentials. However, some reports also sh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wan, Xia, Lu, Yungang, Chen, Xueqin, Xiong, Jian, Zhou, Yuanda, Li, Ping, Xia, Bingqing, Li, Min, Zhu, Michael X., Gao, Zhaobing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062818/ https://www.ncbi.nlm.nih.gov/pubmed/24092046 http://dx.doi.org/10.1007/s00424-013-1345-6

Ejemplares similares

Methods for quantification of pore–voltage sensor interaction in Ca(V)1.2
por: Beyl, S., et al.
Publicado: (2013)

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits
por: Dresviannikov, Andriy V., et al.
Publicado: (2008)

Impact of intracellular hemin on N-type inactivation of voltage-gated K(+) channels
por: Coburger, Ina, et al.
Publicado: (2020)

Gating mechanism of Kv11.1 (hERG) K(+) channels without covalent connection between voltage sensor and pore domains
por: de la Peña, Pilar, et al.
Publicado: (2017)

KCNE1 does not shift TMEM16A from a Ca(2+) dependent to a voltage dependent Cl(-) channel and is not expressed in renal proximal tubule
por: Talbi, Khaoula, et al.
Publicado: (2023)

Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain
por: de la Peña, Pilar, et al.
Publicado: (2018)

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores
por: Zong, Xiangang, et al.
Publicado: (2009)

Channelopathies in Ca(v)1.1, Ca(v)1.3, and Ca(v)1.4 voltage-gated L-type Ca(2+) channels
por: Striessnig, Jörg, et al.
Publicado: (2010)

TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons
por: Menigoz, Aurélie, et al.
Publicado: (2015)

CO(2)-dependent opening of an inwardly rectifying K(+) channel
por: Huckstepp, Robert T. R., et al.
Publicado: (2011)

Physicochemical properties of pore residues predict activation gating of Ca(V)1.2: A correlation mutation analysis
por: Beyl, Stanislav, et al.
Publicado: (2010)

Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1
por: Sørensen, Christiane E., et al.
Publicado: (2022)

Calcineurin-dependent regulation of gap junction conductance and connexin phosphorylation in guinea pig left atrium
por: Jabr, R. I., et al.
Publicado: (2023)

UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria
por: Bondarenko, Alexander I., et al.
Publicado: (2015)

Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels
por: Naik, Jay S., et al.
Publicado: (2018)

Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

The bile acid-sensitive ion channel (BASIC) mediates bile acid-dependent currents in bile duct epithelial cells
por: Wiegreffe, Shari, et al.
Publicado: (2021)

Soluble αKlotho downregulates Orai1-mediated store-operated Ca(2+) entry via PI3K-dependent signaling
por: Kim, Ji-Hee, et al.
Publicado: (2021)

Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation
por: Andranovits, Stanislav, et al.
Publicado: (2017)

Structural basis of PI(4,5)P(2)-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)
por: Seebohm, Guiscard, et al.
Publicado: (2014)

Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1
por: Briones, Rodolfo, et al.
Publicado: (2016)

RBP2 stabilizes slow Cav1.3 Ca(2+) channel inactivation properties of cochlear inner hair cells
por: Ortner, Nadine J., et al.
Publicado: (2019)

The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine
por: Xia, Weiliang, et al.
Publicado: (2013)

Mechanisms Responsible for ω-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains
por: Monteleone, Stefania, et al.
Publicado: (2017)

Cleavage of endogenous γENaC and elevated abundance of αENaC are associated with increased Na(+) transport in response to apical fluid volume expansion in human H441 airway epithelial cells
por: Tan, Chong D., et al.
Publicado: (2011)

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
por: Mandadi, Sravan, et al.
Publicado: (2009)

HL-1 cells express an inwardly rectifying K(+) current activated via muscarinic receptors comparable to that in mouse atrial myocytes
por: Nobles, Muriel, et al.
Publicado: (2010)

Human K(ATP) channelopathies: diseases of metabolic homeostasis
por: Olson, Timothy M., et al.
Publicado: (2009)

Cardiac sodium channelopathies
por: Amin, Ahmad S., et al.
Publicado: (2009)

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S
por: Haerteis, Silke, et al.
Publicado: (2012)

α-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation
por: Bondarava, Maryna, et al.
Publicado: (2009)

Functional consequences of Kir2.1/Kir2.2 subunit heteromerization
por: Panama, Brian K., et al.
Publicado: (2010)

Mechanosensitivity of nicotinic receptors
por: Pan, N. Clara, et al.
Publicado: (2012)

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells
por: Wong, Ching-On, et al.
Publicado: (2010)

TMEM16A knockdown abrogates two different Ca(2+)-activated Cl(−) currents and contractility of smooth muscle in rat mesenteric small arteries
por: Dam, Vibeke Secher, et al.
Publicado: (2013)

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca(2+)
por: Juul, C. A., et al.
Publicado: (2014)

TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model
por: Venturi, Elisa, et al.
Publicado: (2013)

Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P(2)
por: Telezhkin, Vsevolod, et al.
Publicado: (2013)

Regulation of ClC-2 gating by intracellular ATP
por: Stölting, Gabriel, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7janodd16gvlkj7kltc863c609