Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment

Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiandalo, Michael V., Wilton, John, Mohler, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062952/
https://www.ncbi.nlm.nih.gov/pubmed/24948872
http://dx.doi.org/10.7150/ijbs.8780
_version_ 1782321718197485568
author Fiandalo, Michael V.
Wilton, John
Mohler, James L.
author_facet Fiandalo, Michael V.
Wilton, John
Mohler, James L.
author_sort Fiandalo, Michael V.
collection PubMed
description Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more.
format Online
Article
Text
id pubmed-4062952
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-40629522014-06-19 Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment Fiandalo, Michael V. Wilton, John Mohler, James L. Int J Biol Sci Review Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more. Ivyspring International Publisher 2014-06-03 /pmc/articles/PMC4062952/ /pubmed/24948872 http://dx.doi.org/10.7150/ijbs.8780 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Fiandalo, Michael V.
Wilton, John
Mohler, James L.
Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
title Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
title_full Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
title_fullStr Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
title_full_unstemmed Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
title_short Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
title_sort roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062952/
https://www.ncbi.nlm.nih.gov/pubmed/24948872
http://dx.doi.org/10.7150/ijbs.8780
work_keys_str_mv AT fiandalomichaelv rolesforthebackdoorpathwayofandrogenmetabolisminprostatecancerresponsetocastrationanddrugtreatment
AT wiltonjohn rolesforthebackdoorpathwayofandrogenmetabolisminprostatecancerresponsetocastrationanddrugtreatment
AT mohlerjamesl rolesforthebackdoorpathwayofandrogenmetabolisminprostatecancerresponsetocastrationanddrugtreatment

Ejemplares similares