Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis

We have previously reported that a subset of breast tumors are infiltrated with IL-17A-producing tumor-associated lymphocytes and that IL-17A cytokine is principally associated with estrogen receptor negative (ER(−)) and triple negative, basal-like tumors. We established that IL-17A producing lympho...

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Autores principales: Bastid, Jérémy, Bonnefoy, Nathalie, Eliaou, Jean-François, Bensussan, Armand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063083/
https://www.ncbi.nlm.nih.gov/pubmed/25050201
http://dx.doi.org/10.4161/onci.28273
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author Bastid, Jérémy
Bonnefoy, Nathalie
Eliaou, Jean-François
Bensussan, Armand
author_facet Bastid, Jérémy
Bonnefoy, Nathalie
Eliaou, Jean-François
Bensussan, Armand
author_sort Bastid, Jérémy
collection PubMed
description We have previously reported that a subset of breast tumors are infiltrated with IL-17A-producing tumor-associated lymphocytes and that IL-17A cytokine is principally associated with estrogen receptor negative (ER(−)) and triple negative, basal-like tumors. We established that IL-17A producing lymphocytes induced cancer cell proliferation, chemoresistance, and invasion, indicating that IL-17A is a potential therapeutic target for breast malignancies.
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spelling pubmed-40630832015-03-27 Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis Bastid, Jérémy Bonnefoy, Nathalie Eliaou, Jean-François Bensussan, Armand Oncoimmunology Author's View We have previously reported that a subset of breast tumors are infiltrated with IL-17A-producing tumor-associated lymphocytes and that IL-17A cytokine is principally associated with estrogen receptor negative (ER(−)) and triple negative, basal-like tumors. We established that IL-17A producing lymphocytes induced cancer cell proliferation, chemoresistance, and invasion, indicating that IL-17A is a potential therapeutic target for breast malignancies. Landes Bioscience 2014-03-27 /pmc/articles/PMC4063083/ /pubmed/25050201 http://dx.doi.org/10.4161/onci.28273 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Bastid, Jérémy
Bonnefoy, Nathalie
Eliaou, Jean-François
Bensussan, Armand
Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis
title Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis
title_full Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis
title_fullStr Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis
title_full_unstemmed Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis
title_short Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis
title_sort lymphocyte-derived interleukin-17a adds another brick in the wall of inflammation-induced breast carcinogenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063083/
https://www.ncbi.nlm.nih.gov/pubmed/25050201
http://dx.doi.org/10.4161/onci.28273
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