Cargando…

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma

Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway infla...

Descripción completa

Detalles Bibliográficos
Autores principales: Farahani, Rahim, Sherkat, Roya, Hakemi, Mazdak Ganjalikhani, Eskandari, Nahid, Yazdani, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063088/
https://www.ncbi.nlm.nih.gov/pubmed/24949298
http://dx.doi.org/10.4103/2277-9175.133249
_version_ 1782321745626136576
author Farahani, Rahim
Sherkat, Roya
Hakemi, Mazdak Ganjalikhani
Eskandari, Nahid
Yazdani, Reza
author_facet Farahani, Rahim
Sherkat, Roya
Hakemi, Mazdak Ganjalikhani
Eskandari, Nahid
Yazdani, Reza
author_sort Farahani, Rahim
collection PubMed
description Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-α and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well.
format Online
Article
Text
id pubmed-4063088
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-40630882014-06-19 Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma Farahani, Rahim Sherkat, Roya Hakemi, Mazdak Ganjalikhani Eskandari, Nahid Yazdani, Reza Adv Biomed Res Review Article Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-α and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well. Medknow Publications & Media Pvt Ltd 2014-05-28 /pmc/articles/PMC4063088/ /pubmed/24949298 http://dx.doi.org/10.4103/2277-9175.133249 Text en Copyright: © 2014 Farahani http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review Article
Farahani, Rahim
Sherkat, Roya
Hakemi, Mazdak Ganjalikhani
Eskandari, Nahid
Yazdani, Reza
Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
title Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
title_full Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
title_fullStr Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
title_full_unstemmed Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
title_short Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
title_sort cytokines (interleukin-9, il-17, il-22, il-25 and il-33) and asthma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063088/
https://www.ncbi.nlm.nih.gov/pubmed/24949298
http://dx.doi.org/10.4103/2277-9175.133249
work_keys_str_mv AT farahanirahim cytokinesinterleukin9il17il22il25andil33andasthma
AT sherkatroya cytokinesinterleukin9il17il22il25andil33andasthma
AT hakemimazdakganjalikhani cytokinesinterleukin9il17il22il25andil33andasthma
AT eskandarinahid cytokinesinterleukin9il17il22il25andil33andasthma
AT yazdanireza cytokinesinterleukin9il17il22il25andil33andasthma