KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance

Natural killer cells (NK cells) play a key role in cancer immunosurveillance. However, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. Here, we discuss the role of intrinsic master transcription factors and extrinsic IL-15 signaling on NK...

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Detalles Bibliográficos
Autores principales: Renner, Philipp, Rovira, Jordi, Klein, Christoph, Schlitt, Hans-Jürgen, Geissler, Edward K, Kroemer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063134/
https://www.ncbi.nlm.nih.gov/pubmed/25050205
http://dx.doi.org/10.4161/onci.28328
Descripción
Sumario:Natural killer cells (NK cells) play a key role in cancer immunosurveillance. However, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. Here, we discuss the role of intrinsic master transcription factors and extrinsic IL-15 signaling on NK cell-mediated immune protection against murine pulmonary metastasis.

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