KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance

Natural killer cells (NK cells) play a key role in cancer immunosurveillance. However, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. Here, we discuss the role of intrinsic master transcription factors and extrinsic IL-15 signaling on NK...

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Autores principales: Renner, Philipp, Rovira, Jordi, Klein, Christoph, Schlitt, Hans-Jürgen, Geissler, Edward K, Kroemer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063134/
https://www.ncbi.nlm.nih.gov/pubmed/25050205
http://dx.doi.org/10.4161/onci.28328
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author Renner, Philipp
Rovira, Jordi
Klein, Christoph
Schlitt, Hans-Jürgen
Geissler, Edward K
Kroemer, Alexander
author_facet Renner, Philipp
Rovira, Jordi
Klein, Christoph
Schlitt, Hans-Jürgen
Geissler, Edward K
Kroemer, Alexander
author_sort Renner, Philipp
collection PubMed
description Natural killer cells (NK cells) play a key role in cancer immunosurveillance. However, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. Here, we discuss the role of intrinsic master transcription factors and extrinsic IL-15 signaling on NK cell-mediated immune protection against murine pulmonary metastasis.
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spelling pubmed-40631342015-04-08 KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance Renner, Philipp Rovira, Jordi Klein, Christoph Schlitt, Hans-Jürgen Geissler, Edward K Kroemer, Alexander Oncoimmunology Author's View Natural killer cells (NK cells) play a key role in cancer immunosurveillance. However, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. Here, we discuss the role of intrinsic master transcription factors and extrinsic IL-15 signaling on NK cell-mediated immune protection against murine pulmonary metastasis. Landes Bioscience 2014-04-08 /pmc/articles/PMC4063134/ /pubmed/25050205 http://dx.doi.org/10.4161/onci.28328 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Renner, Philipp
Rovira, Jordi
Klein, Christoph
Schlitt, Hans-Jürgen
Geissler, Edward K
Kroemer, Alexander
KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
title KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
title_full KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
title_fullStr KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
title_full_unstemmed KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
title_short KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
title_sort klrg1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063134/
https://www.ncbi.nlm.nih.gov/pubmed/25050205
http://dx.doi.org/10.4161/onci.28328
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