Sleep apnea awakens cancer: A unifying immunological hypothesis

The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OSA, namely, intermittent hypoxia and sleep fragmentation, prom...

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Detalles Bibliográficos
Autores principales: Gozal, David, Almendros, Isaac, Hakim, Fahed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063138/
https://www.ncbi.nlm.nih.gov/pubmed/25050203
http://dx.doi.org/10.4161/onci.28326
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author Gozal, David
Almendros, Isaac
Hakim, Fahed
author_facet Gozal, David
Almendros, Isaac
Hakim, Fahed
author_sort Gozal, David
collection PubMed
description The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OSA, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.
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spelling pubmed-40631382015-03-27 Sleep apnea awakens cancer: A unifying immunological hypothesis Gozal, David Almendros, Isaac Hakim, Fahed Oncoimmunology Author's View The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OSA, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness. Landes Bioscience 2014-03-27 /pmc/articles/PMC4063138/ /pubmed/25050203 http://dx.doi.org/10.4161/onci.28326 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Gozal, David
Almendros, Isaac
Hakim, Fahed
Sleep apnea awakens cancer: A unifying immunological hypothesis
title Sleep apnea awakens cancer: A unifying immunological hypothesis
title_full Sleep apnea awakens cancer: A unifying immunological hypothesis
title_fullStr Sleep apnea awakens cancer: A unifying immunological hypothesis
title_full_unstemmed Sleep apnea awakens cancer: A unifying immunological hypothesis
title_short Sleep apnea awakens cancer: A unifying immunological hypothesis
title_sort sleep apnea awakens cancer: a unifying immunological hypothesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063138/
https://www.ncbi.nlm.nih.gov/pubmed/25050203
http://dx.doi.org/10.4161/onci.28326
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