The microbiome modulates the tumor macroenvironment

Earlier investigations of the tumor microenvironment unveiled systemic networks presenting novel therapeutic opportunities. It has been recently shown that gut microbes modulate whole host immune and neuroendocrine factors impacting the fate of distant preneoplastic lesions toward malignancy or regr...

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Detalles Bibliográficos
Autores principales: Erdman, Susan E, Poutahidis, Theofilos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063141/
https://www.ncbi.nlm.nih.gov/pubmed/25050199
http://dx.doi.org/10.4161/onci.28271
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author Erdman, Susan E
Poutahidis, Theofilos
author_facet Erdman, Susan E
Poutahidis, Theofilos
author_sort Erdman, Susan E
collection PubMed
description Earlier investigations of the tumor microenvironment unveiled systemic networks presenting novel therapeutic opportunities. It has been recently shown that gut microbes modulate whole host immune and neuroendocrine factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. These findings establish a new paradigm of holobiont therapeutic engineering in emerging tumor macroenvironments.
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spelling pubmed-40631412015-03-27 The microbiome modulates the tumor macroenvironment Erdman, Susan E Poutahidis, Theofilos Oncoimmunology Author's View Earlier investigations of the tumor microenvironment unveiled systemic networks presenting novel therapeutic opportunities. It has been recently shown that gut microbes modulate whole host immune and neuroendocrine factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. These findings establish a new paradigm of holobiont therapeutic engineering in emerging tumor macroenvironments. Landes Bioscience 2014-03-27 /pmc/articles/PMC4063141/ /pubmed/25050199 http://dx.doi.org/10.4161/onci.28271 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Erdman, Susan E
Poutahidis, Theofilos
The microbiome modulates the tumor macroenvironment
title The microbiome modulates the tumor macroenvironment
title_full The microbiome modulates the tumor macroenvironment
title_fullStr The microbiome modulates the tumor macroenvironment
title_full_unstemmed The microbiome modulates the tumor macroenvironment
title_short The microbiome modulates the tumor macroenvironment
title_sort microbiome modulates the tumor macroenvironment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063141/
https://www.ncbi.nlm.nih.gov/pubmed/25050199
http://dx.doi.org/10.4161/onci.28271
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