Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression

Tumor relapse after radiotherapy may be due to the upregulation of programmed cell death ligand 1 (PD-L1). We demonstrated that anti-PD-L1 antibody synergizes with radiation to control local and distal tumors. CD8(+)T cells mediated antitumor effects of the combination therapy by the reduction of my...

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Autores principales: Deng, Liufu, Liang, Hua, Burnette, Byron, Weicheslbaum, Ralph R, Fu, Yang-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063144/
https://www.ncbi.nlm.nih.gov/pubmed/25050217
http://dx.doi.org/10.4161/onci.28499
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author Deng, Liufu
Liang, Hua
Burnette, Byron
Weicheslbaum, Ralph R
Fu, Yang-Xin
author_facet Deng, Liufu
Liang, Hua
Burnette, Byron
Weicheslbaum, Ralph R
Fu, Yang-Xin
author_sort Deng, Liufu
collection PubMed
description Tumor relapse after radiotherapy may be due to the upregulation of programmed cell death ligand 1 (PD-L1). We demonstrated that anti-PD-L1 antibody synergizes with radiation to control local and distal tumors. CD8(+)T cells mediated antitumor effects of the combination therapy by the reduction of myeloid-derived suppressor cells (MDSCs) via tumor-necrosis factor (TNF)-mediated signaling. Our study provides insight into immune- and radiation-based combinational therapies.
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spelling pubmed-40631442014-07-21 Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression Deng, Liufu Liang, Hua Burnette, Byron Weicheslbaum, Ralph R Fu, Yang-Xin Oncoimmunology Author's View Tumor relapse after radiotherapy may be due to the upregulation of programmed cell death ligand 1 (PD-L1). We demonstrated that anti-PD-L1 antibody synergizes with radiation to control local and distal tumors. CD8(+)T cells mediated antitumor effects of the combination therapy by the reduction of myeloid-derived suppressor cells (MDSCs) via tumor-necrosis factor (TNF)-mediated signaling. Our study provides insight into immune- and radiation-based combinational therapies. Landes Bioscience 2014-04-17 /pmc/articles/PMC4063144/ /pubmed/25050217 http://dx.doi.org/10.4161/onci.28499 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Deng, Liufu
Liang, Hua
Burnette, Byron
Weicheslbaum, Ralph R
Fu, Yang-Xin
Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
title Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
title_full Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
title_fullStr Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
title_full_unstemmed Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
title_short Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
title_sort radiation and anti-pd-l1 antibody combinatorial therapy induces t cell-mediated depletion of myeloid-derived suppressor cells and tumor regression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063144/
https://www.ncbi.nlm.nih.gov/pubmed/25050217
http://dx.doi.org/10.4161/onci.28499
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