Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression

Tumor relapse after radiotherapy may be due to the upregulation of programmed cell death ligand 1 (PD-L1). We demonstrated that anti-PD-L1 antibody synergizes with radiation to control local and distal tumors. CD8(+)T cells mediated antitumor effects of the combination therapy by the reduction of my...

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Detalles Bibliográficos
Autores principales: Deng, Liufu, Liang, Hua, Burnette, Byron, Weicheslbaum, Ralph R, Fu, Yang-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063144/
https://www.ncbi.nlm.nih.gov/pubmed/25050217
http://dx.doi.org/10.4161/onci.28499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063144/
https://www.ncbi.nlm.nih.gov/pubmed/25050217
http://dx.doi.org/10.4161/onci.28499

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